Value of ECV quantification in PAH: correlation with echocardiographic, MRI and serum biomarkers

Background The evaluation of right ventricle (RV) function is paramount in pulmonary hypertension (PAH) although it can be difficult to assess. Right ventricular myocardial fibrosis assessed using late gadolinium enhancement (LGE) has been correlated with right ventricular function and prognosis. Myocardial fibrosis can be evaluated by several methods, including LGE, ECV quantification using native and post contrast T1 mapping sequence and serum markers of collagen turnover. Value of ECV quantification and it’s correlation with other biomarkers has not been systematically assessed during PAH. The goal of that study is to compare ECV, echo longitudinal strain, and serum markers of collagen turnover in the assessment of myocardial fibrosis in a population of adults with PAH.